Forskare, farmakologi

Sök bland 12 lediga jobb som Forskare, farmakologi och börja ditt nya yrkesliv idag!

Postdoktor i leukemi mikromiljö

Vill du bidra till medicinsk forskning i leukemi mikromiljö? Den utvalda kandidaten kommer att arbeta och utbildas i http://ki. se/en/medh/hong-qian-groupvid https://ki.se/en/medh/center-for-hematology-and-regenerative-medicine-herm, Institutionen för medicin Huddinge, Flemingsberg Campus. Hong Qians grupp syftar till att reda ut rollen av hematopoetisk nisch inklusive mesenkymala stamceller i myeloid leukemi. Det slutliga målet är att identifiera nya nischbaserade terapeutiska mål för bättre behandlingsresultat av sjukdomarna. Gruppen har hittills främst fokuserat på den mesenkymala nischen vid myeloisk leukemi hos patienter och musmodeller. Gruppen har identifierat en uppsättning molekyler som är dysreglerade i leukemi nischen. Bland dem har vi visat att Lama4, en receptorbindande kedja av extracellulära matrixprotein-lamininisoformer, hämmar akut myeloisk leukemi progression och återfall (Cai, et al., Blood, 2022) och CXCL14, en kemokin, undertrycker överlevnad av kronisk myeloisk leukemi-initierande stamceller (Dolinska, Cai, Månsson et al., Blood 2023). Din roll Du kommer som postdoktoral forskare att bedriva forskningen med särskilt fokus på att dechiffrera molekylära vägar som förmedlar interaktion med leukemiska stamceller med sin nisch under överinseende av gruppledaren (Dr. Hong Qian). Dessutom förväntas kandidaten också delta i samarbetsprojekt. De huvudsakliga teknikerna som används inkluderar flerfärgsflödescytometri, konfokal avbildning, linjespårning, in vivo och in vitro stamcellsanalyser inklusive samodling och transplantation, såväl som avancerade molekylära verktyg, såsom RNA-sekvensering, digital PCR och encellig PCR. Du kommer som postdoktoral forskare att få en unik möjlighet att arbeta nära tillsammans med spetsforskare och att bidra till högkvalitativ forskning om interaktioner mellan leukemiska stamceller och deras nischer. Vem är du? För att anställas som postdoktor krävs avlagd doktorsexamen eller en utländsk examen som bedöms motsvara doktorsexamen. Detta behörighetskrav ska vara uppfyllt senast vid tidpunkten då anställningsbeslutet fattas. Det är meriterande om du har avlagt din doktorsexamen inom de tre senaste åren, om det finns särskilda skäl kan din examen ha avlagts tidigare. Vi söker dig som har forskning och labberfarenhet inom området blodsjukdomar. Det anses meriterande om den sökande har erfarenhet av flerfärgsflödescytometri och musmodell. Vi lägger stor vikt vid personlig lämplighet och söker en mycket motiverad medarbetare som uppskattar att arbeta i team samtidigt som du har en hög grad av självständighet. Nödvändiga krav - Doktorsexamen i hematologi, eller stamcell biologi eller cell och molekular biologi - Beprövad erfarenhet av att genomföra och publicera högkvalitativa studier i peer-reviewed tidskrifter - Bra samarbetsförmåga i en teammiljö - Utmärkt förmåga att organisera sitt arbeta och har ett bra detaljfokus - Duktig på att kommunicera, både i tal som skrift - Flytande engelska, både i tal som skrift - Minst magisterexamen i molekylär- och cellbiologi eller biomedicin eller medicin - Goda kunskaper i engelska i tal och skrift - Stark organisatorisk förmåga och detaljorienterad - Erfarenhet av flödescytometri - Erfarenhet av cellodling, särskilt samodling med mesenkymala stamceller. Önskade krav Erfarenhet av leukemi nisch Erfarenhet av drogtester Erfarenhet av musarbete Meriterande; kunskaper, färdigheter och erfarenhet - Forskningserfarenhet av studier inom leukemi, stamceller, tumor mikromiljö. - Intresse för utveckling inom områdena leukemi nische - Kunskap av svenska eller annat skandinaviskt språk Vad erbjuder vi? En kreativ, internationell inspirerande miljö fylld av kompetens och nyfikenhet. Karolinska Institutet är ett av världens ledande medicinska universitet. Här bedriver vi framgångsrik medicinsk forskning och har det största utbudet av medicinska utbildningar i Sverige. På KI får du träffa forskare med olika forskningsinriktningar som jobbar tillsammans. Det är det gränsöverskridande samarbetet som bidrar till KI:s världsledande position inom forskning. Flera av de personer du möter inom vården är utbildade på KI. En nära relationen till hälso- och sjukvården är viktig för att skapa utbildning och forskning av högsta kvalitet. Som universitet är Karolinska Institutet också en statlig myndighet. Det gör att du som anställd får goda förmåner genom vårt kollektivavtal. Placering: Flemingsberg Ansökan Ansökan ska bestå av följande handlingar, skrivna på engelska eller svenska: - En komplett CV inkluderande disputationsdatum, avhandlingens titel, tidigare akademiska befattningar, akademisk titel, nuvarande befattning, akademiska utmärkelser samt kommittéarbete - En komplett publikationslista - En sammanfattning av nuvarande arbete (maximalt en sida) Varmt välkommen med din ansökan senast den 2024-05-03. Ansökan ska göras via rekryteringssystemet Varbi. Vill du göra skillnad – och bidra till en bättre hälsa för alla? Sök jobb hos oss

22 mars 2024
Sista ansökan:
3 maj 2024
Postdoktor i leukemi mikromiljö

Vill du bidra till medicinsk forskning i leukemi mikromiljö? Den utvalda kandidaten kommer att arbeta och utbildas i http://ki. se/en/medh/hong-qian-groupvid https://ki.se/en/medh/center-for-hematology-and-regenerative-medicine-herm, Institutionen för medicin Huddinge, Flemingsberg Campus. Hong Qians grupp syftar till att reda ut rollen av hematopoetisk nisch inklusive mesenkymala stamceller i myeloid leukemi. Det slutliga målet är att identifiera nya nischbaserade terapeutiska mål för bättre behandlingsresultat av sjukdomarna. Gruppen har hittills främst fokuserat på den mesenkymala nischen vid myeloisk leukemi hos patienter och musmodeller. Gruppen har identifierat en uppsättning molekyler som är dysreglerade i leukemi nischen. Bland dem har vi visat att Lama4, en receptorbindande kedja av extracellulära matrixprotein-lamininisoformer, hämmar akut myeloisk leukemi progression och återfall (Cai, et al., Blood, 2022) och CXCL14, en kemokin, undertrycker överlevnad av kronisk myeloisk leukemi-initierande stamceller (Dolinska, Cai, Månsson et al., Blood 2023). Din roll Du kommer som postdoktoral forskare att bedriva forskningen med särskilt fokus på att dechiffrera molekylära vägar som förmedlar interaktion med leukemiska stamceller med sin nisch under överinseende av gruppledaren (Dr. Hong Qian). Dessutom förväntas kandidaten också delta i samarbetsprojekt. De huvudsakliga teknikerna som används inkluderar flerfärgsflödescytometri, konfokal avbildning, linjespårning, in vivo och in vitro stamcellsanalyser inklusive samodling och transplantation, såväl som avancerade molekylära verktyg, såsom RNA-sekvensering, digital PCR och encellig PCR. Du kommer som postdoktoral forskare att få en unik möjlighet att arbeta nära tillsammans med spetsforskare och att bidra till högkvalitativ forskning om interaktioner mellan leukemiska stamceller och deras nischer. Vem är du? För att anställas som postdoktor krävs avlagd doktorsexamen eller en utländsk examen som bedöms motsvara doktorsexamen. Detta behörighetskrav ska vara uppfyllt senast vid tidpunkten då anställningsbeslutet fattas. Det är meriterande om du har avlagt din doktorsexamen inom de tre senaste åren, om det finns särskilda skäl kan din examen ha avlagts tidigare. Vi söker dig som har forskning och labberfarenhet inom området blodsjukdomar. Det anses meriterande om den sökande har erfarenhet av flerfärgsflödescytometri och musmodell. Vi lägger stor vikt vid personlig lämplighet och söker en mycket motiverad medarbetare som uppskattar att arbeta i team samtidigt som du har en hög grad av självständighet. Nödvändiga krav - Doktorsexamen i hematologi, eller stamcell biologi eller cell och molekular biologi - Beprövad erfarenhet av att genomföra och publicera högkvalitativa studier i peer-reviewed tidskrifter - Bra samarbetsförmåga i en teammiljö - Utmärkt förmåga att organisera sitt arbeta och har ett bra detaljfokus - Duktig på att kommunicera, både i tal som skrift - Flytande engelska, både i tal som skrift - Minst magisterexamen i molekylär- och cellbiologi eller biomedicin eller medicin - Goda kunskaper i engelska i tal och skrift - Stark organisatorisk förmåga och detaljorienterad - Erfarenhet av flödescytometri - Erfarenhet av cellodling, särskilt samodling med mesenkymala stamceller. Önskade krav Erfarenhet av leukemi nisch Erfarenhet av drogtester Erfarenhet av musarbete Meriterande; kunskaper, färdigheter och erfarenhet - Forskningserfarenhet av studier inom leukemi, stamceller, tumor mikromiljö. - Intresse för utveckling inom områdena leukemi nische - Kunskap av svenska eller annat skandinaviskt språk Vad erbjuder vi? En kreativ, internationell inspirerande miljö fylld av kompetens och nyfikenhet. Karolinska Institutet är ett av världens ledande medicinska universitet. Här bedriver vi framgångsrik medicinsk forskning och har det största utbudet av medicinska utbildningar i Sverige. På KI får du träffa forskare med olika forskningsinriktningar som jobbar tillsammans. Det är det gränsöverskridande samarbetet som bidrar till KI:s världsledande position inom forskning. Flera av de personer du möter inom vården är utbildade på KI. En nära relationen till hälso- och sjukvården är viktig för att skapa utbildning och forskning av högsta kvalitet. Som universitet är Karolinska Institutet också en statlig myndighet. Det gör att du som anställd får goda förmåner genom vårt kollektivavtal. Placering: Flemingsberg Ansökan Ansökan ska bestå av följande handlingar, skrivna på engelska eller svenska: - En komplett CV inkluderande disputationsdatum, avhandlingens titel, tidigare akademiska befattningar, akademisk titel, nuvarande befattning, akademiska utmärkelser samt kommittéarbete - En komplett publikationslista - En sammanfattning av nuvarande arbete (maximalt en sida) Varmt välkommen med din ansökan senast den 2024-05-03. Ansökan ska göras via rekryteringssystemet Varbi. Vill du göra skillnad – och bidra till en bättre hälsa för alla? Sök jobb hos oss

22 mars 2024
Sista ansökan:
3 maj 2024
Scientist/Senior Scientist - Early Product Dev and Mfg

Are you ready to make a significant impact on the development of new medicines? Join us at AstraZeneca's Early Product Development and Manufacture (EPDM) unit in Gothenburg, Sweden. We are accountable for delivering a vast portfolio of early investigational medicinal products, supplying different types of clinical trial material to studies across the globe. This is your chance to explore and innovate in our dynamic environment! This is an exciting opportunity to join our Pharmaceutical Sciences department which is accountable for the design and development of synthetic routes, preclinical and phase I/II formulations, encompassing both small molecules and new modalities such as mRNA and oligonucleotides, across the whole range of AstraZeneca's therapeutic areas. The role will be offered at Scientist or Senior Scientist level, depending on your background and experience. What you will do As part of the EPDM manufacturing unit, you will work in a GMP (Good Manufacturing Practice) environment, contributing to the delivery of clinical results. Your role will focus on the manufacturing of drug product, with responsibilities including timely manufacture of various drug products, working with practical hands-on processes in our GMP facilities, monitoring regulatory requirements, supporting documentation activities, and driving initiatives to improve flexibility and productivity. Accountabilities include: * Work with practical hands-on processes in our GMP facilities following manufacturing batch records and perform transactions in material management systems. * Assume responsibilities toward timely manufacture of various drug products in line with the plans agreed within EPDM and surrounding stakeholders. * Monitor, secure and follow up on other regulatory requirements according to GMP through associated IT-systems. * Rapidly develop strong competence within relevant process technologies and build credibility and ability to drive and secure product establishment, scale-up and clinical manufactures. * Support documentation activities, e.g. by authoring manufacturing batch records, taking part in deviation investigations, authoring SOPs, and other guidance documents, change control processes etc. * Assess records and report manufacturing and validation data accurately according to GMP. * Ensure that SHE (Safety Health and Environment) and GMP standards are upheld and ensure AZ Policies and Standards are understood and followed. * Be entrepreneurial and drive initiatives to further improve flexibility and productivity, resulting in shorter lead times or increased value for our customers and patients. Essential requirements * MSc or BSc in pharmacy/engineering or extensive GMP-manufacturing experience from the pharmaceutical industry * Excellent collaboration, communication, and planning skills * Strong sense of responsibility, teamwork and delivery focus * Strong verbal and documentation skills in English * Keen interest to learn and operate complex manufacturing equipment Desirable for the role * Experience from pharmaceutical development or working in a manufacturing or supply chain organisation * Experience from sterile manufacture * Experience with material management systems * Ability to author manufacturing batch records, SOPs, and other guidance documents * Experience with deviation investigations and change control processes * Familiarity with SHE standards Why AstraZeneca At AstraZeneca, we follow the science to explore and innovate. We are unlocking the power of what science can do, working towards treating, preventing, modifying and even curing some of the world's most complex diseases. If you're driven by curiosity and courage, inspired by the possibility of doing things that have never been done before, this is the place for you. So, what's next? We welcome your application (including CV and cover letter), no later than April 7th, 2024. Additional information Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

22 mars 2024
Sista ansökan:
1 april 2024
Associate Scientist/Operational Technologist

Associate Scientist/Operational Technologist – Drug Product Delivery at AstraZeneca in Gothenburg We are currently seeking two Associate Scientists/Operational Technologists to join AstraZeneca in Gothenburg. This role presents an excellent chance for you to expand your knowledge of pharmaceutical development by collaborating closely with experienced operators. Purpose, Offer and Benefits This is a consulting assignment starting in May and extending until November. You will be employed by TNG during the assignment period. AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. Your Responsibilities This role contributes to the packaging of drug products in development phase for clinical studies. All below activities will have an impact on the speed, quality and cost of the AZ development portfolio. Practical hands-on work in our Good Manufacturing Practice (GMP) facilities with dedicated tasks in close collaboration and to support DPD Scientist/Senior Scientist e.g. assisting GMP operators with: • Preparation of process rooms and equipment before and after clinical manufacture • Assembly/disassembly and cleaning of equipment • Primary packing, i.e. packing of tablets/capsules in bottles (manually or automated) • Secondary packing, i.e. labelling of study material (manually or automated) • Working according to SHE (Safety Health and environment) and GMP standards  The Bigger Picture The role is intended to be used in a flexible way to resolve short term bottle necks. The role holder will not become fully qualified as a GMP operator but will be able to carry out much of the work expected from operators under supervision. Our Expectations • You must have completed your studies at upper secondary school level e.g. in natural/technical sciences • It is essential that you follow written procedures carefully and document executed tasks. • GMP knowledge is desirable • Interest in technique and manufacturing equipment and practical hands-on work is desirable • You need to be flexible (temporary positions) with good team working skills. • Good knowledge of oral and written English is a requirement Interested? This is a staffing assignment which means that you are employed by TNG, but work for one of our customers. If you are interested in this position, apply right now! The selection process is ongoing and the position can be filled before the last apply-date. If you have any questions, please contact the recruiter.

19 mars 2024
Sista ansökan:
29 mars 2024
Clinical Pharmacology Expert in CVRM

Clinical Pharmacology Expert (Director or Associate Director) in CVRM Do you have expertise and experience in clinical pharmacology, PK, PKPD, Model Informed Drug Development (MIDD) and its application in drug development? Would you like to apply your expertise in a company that is following the science and turn ideas into life changing medicines? If yes, we have the position for you at AstraZeneca! We now have an exciting opportunity for an engaged and diligent individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca at our vibrant Gothenburg site in Sweden, as Associate Director or Director depending on your experience and skills. This is a global role that will support large- and small molecule projects across all phases of clinical development within the therapy area of Cardiovascular, Renal and Metabolism. We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Within the Clinical Pharmacology and Safety Sciences (CPSS) function at AstraZeneca, we have a groundbreaking Clinical Pharmacology and Quantitative Pharmacology (CPQP) organization with a diverse and uniquely skilled team of clinical pharmacometricians, clinical pharmacology scientists and other experts. You will thrive in an energising environment where challenging work goes hand in hand with development. With opportunities, recognition and inquisitive minds, there's no better place to unlock learning and build a long-term career. Gothenburg is a key research and development location for our Cardiovascular, Renal and Metabolism area. What you will do Working closely with clinical pharmacometricians, physicians and other scientists, you will apply your expertise and leadership skills to contribute to the strategy of the clinical development program and the design and interpretation of clinical studies. You will influence key decisions in early and late phases of clinical development. In collaboration with clinical pharmacometricians, you will represent CPQP in cross-functional project teams, and be responsible for developing the clinical pharmacology strategy. The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. You will take part in finding opportunities to apply model informed drug development to accelerate and advise decision making. Based on your interest, skills and experience, you might also perform some pharmacokinetic and pharmacometrics modelling and simulation acting as a dual Clinical Pharmacometrician/Clinical Pharmacologist. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals. Minimum requirements for the role * PhD in clinical pharmacology or other relevant area * Good knowledge of pharmacokinetics, PKPD and Clinical Pharmacology * Biological understanding of disease and drug action * Good oral and written communication skills Desirable in the role * 3+ years of industry experience or equivalent in pharmacokinetics and clinical pharmacology in drug development * Track record in creating and delivering on clinical pharmacology strategies of both small and large molecules * Early and late phase clinical development experience * Good knowledge and experience in use of PK and PKPD modelling and its clinical application * Recognized clinical pharmacology expertise as demonstrated by scientific publishing in the field of clinical pharmacology We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. You have a real passion for your subject, along with a collaborative nature and ability to work in multi-disciplinary global teams. Why AstraZeneca? We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Collaborate in an inclusive environment, a place full of bold new opportunities. Be empowered to be innovative and creative where difference is valued. So, what's next! Does this sound like your next challenge? Apply today! We look forward to find out more about you. Send in your application as soon as possible as we will review applications continuously. For more information about the position please contact the hiring manager, Angelica Quartino (https://www.linkedin.com/in/angelica-quartino-352a7b2/) Where can I find out more? Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Life in Gothenburg site: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Read more about BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/

18 mars 2024
Sista ansökan:
28 mars 2024
Postdoktor inom Molekylära mekanismer för läkemedel

Vill du arbeta med forskning, med stöd av kompetenta och trevliga kollegor i en internationell miljö? Vill du ha en arbetsgivare som satsar på ett hållbart medarbetarskap och erbjuder trygga, förmånliga arbetsvillkor? Välkommen att söka anställning som Postdoktor vid institutionen farmaceutisk biovetenskap på Uppsala universitet. Institutionen för farmaceutisk biovetenskap • En del av något stort Institutionen för farmaceutisk biovetenskap är en interdisciplinär miljö där 10 forskningsområden arbetar för att bidra till bättre läkemedel och en friskare värld. Med laboratorier i hjärtat av Uppsala Biomedicinskt Centrum och Sveriges enda Farmaceutiska fakultet utgör vi en vital motor i utvecklingen av utbildning och forskning inom de farmaceutiska vetenskaperna.  Mer information om institutionen och dess verksamhet finns på http://www.farmbio.uu.se. Arbetsuppgifter Du kommer att arbeta ett multidisciplinärt team vid institutionen för farmaceutisk biovetenskap, som involverar expertis inom kemi, farmakodynamik, farmakologi och bioinformatik. Projektet är en del av ett strategiskt samarbete vid institutionen som involverar grupperna farmakognosi (Ulf Göransson), translationell läkemedelsutveckling (Hans Lennernäs), farmaceutisk bioinformatik (Ola Spjuth), farmaceutisk cellbiologi (Johan Lennartsson, Johan Heldin), och strukturell proteomik (Erik Jansson). Du kommer att arbeta nära tillsammans med en post doc i bioinformatik, och målet med ditt arbete är att beskriva verkningsmekanismer med hjälp av proteomik och cellbaserade tekniker. Du bör ha en stark experimentell bakgrund, inom fältet mellan kemi och biologi. Projektet bygger på användningen av cellkulturer, masspektrometribaserad proteomik och bildanalys, som härrör från ett intresse för vissa klasser av kemiska föreningar. Inledningsvis kommer du att studera farmakodynamik och resistensutveckling mot idag använda cytostatika och effekterna av en panel av nya kemiska föreningar. Kvalifikationskrav - Doktorsexamen inom farmaceutisk/medicinskt område eller angränsade område eller en utländsk examen som bedöms motsvara doktorsexamen inom angivna område. Examen ska vara uppfyllt senast vid tidpunkten då anställningsbeslutet fattas. Främst bör den komma ifråga som har avlagt examen för högst tre år sedan. Vid beräkning av ramtiden om tre år är utgångspunkten sista ansökningsdag. Om det finns särskilda skäl kan sådan examen ha avlagts tidigare. Med särskilda skäl avses ledighet på grund av sjukdom, föräldraledighet, förtroendeuppdrag inom fackliga organisationer, etc. - Ett stort intresse för läkemedelsupptäckt och läkemedelsutveckling. - Visad erfarenhet av att arbeta i tvärvetenskapliga projekt. - Erfarenhet av medicinsk kemi och cellodling. - Erfarenhet inom ett eller flera av följande områden: strukturaktivitetsstudier, masspektrometri, proteomik, cellbaserad assays - Kunskaper i farmakologi och erfarenhet av klargörande av verkningsmekanismer - Utmärkt kommunikationsförmåga i skriftlig och muntlig engelska, liksom god dokumentationsförmåga. Önskvärt/meriterande i övrigt - Erfarenhet av forskningsarbete efter din doktorsexamen - Erfarenhet av TPP proteomik. - Erfarenhet av cell-painting assays - Kunskaper om bioinformatik - Erfarenhet av klargörande av verkningsmekanismer Om anställningen  Anställningen är tidsbegränsad i 2 år enligt centralt kollektivavtal. Omfattningen är heltid. Tillträde 240408 eller enligt överenskommelse. Placeringsort: Uppsala Upplysningar om anställningen lämnas av: Professor Ulf Göransson, e-post: [email protected] och professor Hans Lennernäs,  e-post [email protected] För frågor runt anställningen: administrativ chef Marina Rönngren, e-post [email protected] Välkommen med din ansökan senast den 4 april 2024, UFV-PA 2024/815. Uppsala universitet är ett brett forskningsuniversitet med stark internationell ställning. Det yttersta målet är att bedriva utbildning och forskning av högsta kvalitet och relevans för att göra skillnad i samhället. Vår viktigaste tillgång är alla 7 600 anställda och 53 000 studenter som med nyfikenhet och engagemang gör Uppsala universitet till en av landets mest spännande arbetsplatser. Läs mer om våra förmåner och hur det är att jobba inom Uppsala universitet https://uu.se/om-uu/jobba-hos-oss/ Vi undanber oss erbjudanden om rekryterings- och annonseringshjälp. Ansökan tas emot i Uppsala universitets rekryteringssystem.

13 mars 2024
Sista ansökan:
4 april 2024
Biologics Translational PKPD Modeling & DMPK Expert

Do you have a passion for PKPD modelling of antibody-based therapeutics and expertise in respiratory and immunology? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for! We currently have an exciting opportunity for a passionate PKPD modelling and DMPK Scientist to join our DMPK department as a Biologics Translational PKPD Modeling & DMPK Specialist within Early Respiratory and Immunology (R&I). The R&I DMPK department provides drug metabolism and pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio. This position is located at AstraZeneca's vibrant R&D site in Gothenburg, Sweden. At AstraZeneca Early Respiratory & Immunology (R&I), we're proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. What you'll do? As a Biologics Translational PKPD Modelling & DMPK Specialist (Principal Scientist) you will have the opportunity to drive strategy and provide global leadership in PKPD science across our diverse portfolio, and act as role model, mentoring and guiding less experienced members of the team. You have in-depth knowledge of biologics drug discovery and a keen interest in understanding the translational PKPD of antibody-based therapeutics. In the role you would provide projects with specialist modeling input into exploring PK/PD/Efficacy in pre-clinical models and use them to guide an understanding of the dosing across different patient populations. Main Duties and Responsibilities: * Be the key link between the leadership team and department in driving the translational PKPD strategy and leveraging modeling approaches in discovery projects towards human dose predictions * Drive and embed strategic direction by developing and implementing best practices in supporting projects and share insight across the department * Able to handle and balance the workload of multiple projects and efficiently manage your time and submit pragmatic solutions/strategies to ensure effective support of your projects * Represent early R&I DMPK in projects and providing overall scientific leadership for cross functional collaborations involving DMPK * Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP) * Ensuring that translational PKPD approaches are embedded at the heart of project strategy and used to support design of appropriate experiments that are aligned to the strategy underpinning human dose prediction and providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria * Identify, champion and develop new ideas * Offer a breadth of influence and impact across AstraZeneca DMPK * Leading scientific discipline networks and acting as a focus for debate within the AstraZeneca scientific community * Develop excellent working relations with key stakeholders within both DMPK and in the project teams, to ensure strategic alignment, strong cross discipline collaboration and communication. Essential for the role * PhD (or equivalent industrial experience) in a relevant field e.g. pharmacokinetics, pharmacology, biopharmaceutics etc. * 7 years of industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on biologics * In-depth knowledge of therapeutic antibody drug discovery (incl. complex biologics, cell therapies, ADCs) and a keen interest in understanding the translational PKPD of antibody based molecules * Experience of DMPK project facing role in pharmaceutical R&D with a variety of therapeutic antibody formats (e.g. mAbs, Fabs, bispecifics, ADCs etc). * Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost * Excellent interpersonal skills, and ability to work in cross-functional teams as well as strong scientific leadership skills * Experience in defining quantitative modeling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies) * Hands on experience of using specialist tools such as WinNonLin/Phoenix, MATLAB, R, Berkely Madonna or similar Why AstraZeneca? At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development. What's next! If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until March 15, 2024. For more information about the position, please contact recruiting manager Nina Lawrence at [email protected]

12 mars 2024
Sista ansökan:
31 mars 2024
Scientist, Protein Expression

The Bigger Picture Our mission is to build foundational technologies to advance human health. We believe rebels dare to question the status quo. Rebels solve the impossible. Rebels build the breakthroughs that define our future. We are rebels. You'll be joining a team who has worked on the frontier of machine learning and synthetic biology at Google X, Stanford, UCSF, KTH, Thermo Fisher, and Enveda Biosciences. Our team is focused on accelerating the science of human health and ultimately change the trajectory of humanity. Join us and build the future. The Role We are looking for a creative Scientist to join our Protein Science team. You will work closely with members of our technical team to provide feedback and brainstorm on novel ways to integrate technology with the biological capabilities we are developing. In this role you will be given the opportunity to truly drive innovations from start to finish, typically with tight deadlines and complex coordination exercises. This role is available at our HQ and lab facilities at the Karolinska Institute in Stockholm. Key Responsibilities Drive the development of in-house protein expression capabilities with a range of expression systems. Independently conduct end-to-end protein expression experiments starting from DNA preparation to protein purification. Coordinate and collaborate with stakeholders from across the organization, including management team and technical platform teams. Drive cutting-edge innovation and follow best practices in research. Qualifications Advanced degree (PhD or equivalent experience) in Protein Science, Natural Sciences, or a related field. Experience working independently with a wide range of protein expression systems for small scale and large scale production. A strong ability to think from first principles while troubleshooting failed experiments or deriving novel ideas. Exposure to lab automation for high-throughput experimentation is a plus. Experience working with data scientists or ML practitioners is a plus. Effective communicator, problem solver, and collaborator with both technical and scientific teams. Ability to own your work and drive outcomes in a fast-paced startup environment. Application process The selection and interview process is ongoing. Please send your application to [email protected]. We look forward to learning more about you! IONLACE is an equal opportunity employer and we actively seek to create a diverse and inclusive workplace. We welcome applications from all qualified individuals regardless of their background.Join on our mission to reimagine the relationship between technology and biology.

12 mars 2024
Sista ansökan:
11 april 2024
Scientist, Assay Development

The Bigger Picture Our mission is to build foundational technologies to advance human health. We believe rebels dare to question the status quo. Rebels solve the impossible. Rebels build the breakthroughs that define our future. We are rebels. You'll be joining a team who has worked on the frontier of machine learning and synthetic biology at Google X, Stanford, UCSF, KTH, Thermo Fisher, and Enveda Biosciences. Our team is focused on accelerating the science of human health and ultimately change the trajectory of humanity. Join us and build the future. The Role We are looking for a creative Scientist to join our Assay Development team. You will develop and drive novel initiatives in the Assay Development team. You will own projects from inception to completion while coordinating with stakeholders across the organization. You will work closely with members of our technical team to provide feedback and brainstorm on novel ways to integrate technology with the biological capabilities we are developing. In this role you will be given the opportunity to truly drive innovations from start to finish, typically with tight deadlines and complex coordination exercises. This role is available at our HQ and lab facilities at the Karolinska Institute in Stockholm. Key Responsibilities Drive proteomics assay development efforts from inception to completion, not limited to ideation, wet lab execution, data analysis and scale up. Coordinate and collaborate with stakeholders from across the organization, including management team and technical platform teams. Drive cutting-edge innovation and follow best practices in research. Qualifications Advanced degree (PhD or equivalent experience) in Molecular Biology, Natural Sciences, or a related field. Experience working with high-throughput assay development e.g., novel immunoassays, NGS and display technologies. A strong ability to think from first principles while troubleshooting failed experiments or deriving novel ideas. Exposure to lab automation for high-throughput experimentation is a plus. Experience working with data scientists or ML practitioners is a plus. Effective communicator, problem solver, and collaborator with both technical and scientific teams. Ability to own your work and drive outcomes in a fast-paced startup environment. Application process The selection and interview process is ongoing. Please send your application to [email protected]. We look forward to learning more about you! IONLACE is an equal opportunity employer and we actively seek to create a diverse and inclusive workplace. We welcome applications from all qualified individuals regardless of their background.Join on our mission to reimagine the relationship between technology and biology.

12 mars 2024
Sista ansökan:
11 april 2024
Preclinical and Translational PK & PKPD Scientist

Do you have expertise in mathematical modelling and/or pharmacokinetics and pharmacodynamics? Would you like to apply your knowledge in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for to be part of the development of future treatment within respiratory and immunology. Our team is growing, and we now have two openings for highly skilled and passionate scientists with expertise in mathematical modelling, preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD), to join the Drug Metabolism and Pharmacokinetics (DMPK) team of project leads within the Early Respiratory and Immunology (R&I) therapeutic area at AstraZeneca in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, thinking big and working together to make the impossible a reality. Early R&I is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and life-cycle management. At AstraZeneca we are proud to have an outstanding workplace culture that encourages innovation and teamwork. We are united by our vision to push the boundaries of DMPK science to transform ideas into medicines for R&I patients. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity toward delivering candidate drugs into late-stage development. What you'll do? You have a true passion for science and will support our portfolio within the R&I therapeutic area. We believe that you have solid, hands-on experience of PKPD modeling and that you will be able to provide expert advice and interpretation of complex drug discovery data. You will deliver translational quantitative/PKPD input for a broad range of drug modalities from target identification to life-cycle management. Main Duties and Responsibilities include: * Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made * Inform and influence the design of studies, with PKPD in mind to answer relevant pharmacological questions and report results and interpretations to project teams and internal governance bodies * Design preclinical PKPD studies, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies * Integrate the appropriate data to predict human pharmacokinetics, efficacious human drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen. This is done in close collaboration with other functions (biologists, safety scientists, clinical pharmacologist and clinical pharmacometricians) * Communicate scientific progress to internal and external stakeholders Depending on your background, experience and skills, your initial career level will be a Senior Scientist, Associate Principal Scientist or Principal Scientist. Essential for the role The successful candidate is expected to have a solid PKPD understanding and hands on experience of mathematical modelling (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, quantitative systems pharmacology (QSP) models). * PhD or equivalent in relevant field, with a focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting * Hands-on experience with modelling software (e.g. Phoenix WinNonlin, Matlab, Monolix, R, NONMEM, or similar) * Proven scientific leadership and ability to mentor junior colleagues * Experience in project leadership and collaborative mindset * Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts * Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently * Proactive and excellent communication skills Work policy When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. What's next? This is an exciting opportunity for a talented modeller to join a strong team and support the portfolio of a major pharmaceutical company that has science at its heart whilst being based in the wonderful city of Gothenburg, Sweden. If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until March 31, 2024. For more information about the position, please contact recruiting manager Nina Lawrence at [email protected] Where can I find out more? Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Life in Gothenburg: https://www.movetogothenburg.com/ Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

8 mars 2024
Sista ansökan:
29 mars 2024