Astrazeneca AB jobb

Are you an experienced Discovery Safety Specialist/Toxicologist? Would you like to bring your scientific excellence to BioPharma Safety and become a key player in the discovery of safe innovative medicines? If yes, this might be your next career step! We are looking for a motivated individual to join us as an Associate Director, Discovery Safety Specialist/Toxicologist to strengthen the BioPharma Discovery Safety team with a focus on cardiovascular, renal, metabolism and respiratory drug projects. You will bring critical safety-expertise to BioPharma Safety within the larger function of Clinical Pharmacology and Safety Sciences (CPSS). The position will be placed either at our vibrant R&D site in Gothenburg, Sweden or in Cambridge Biomedical Campus, UK. The BioPharma Discovery Safety team develop and apply innovative scientific strategies to drive the design and selection of safe medicines for patients suffering from Cardiovascular, Renal and Metabolic (CVRM) diseases as well as respiratory diseases. Within Clinical Pharmacology and Safety Sciences, we put a strong emphasis on talent development. You will be able to develop your scientific leadership by working together with leaders in investigative toxicology, drug discovery, cell biology, and predictive safety science. Accountabilities: As true Drug Hunting partners to BioPharma R&D, we contribute to the selection of novel drug targets, design of therapeutic concepts, identification and optimization of different modalities, and the selection of novel candidate drugs. We develop and apply cutting edge molecular, cellular and in vivo technologies to push the boundaries of predictive safety science and investigative toxicology. You will also be responsible for the safety strategy in multi-disciplinary drug discovery project teams and provide scientific leadership to influence project decision making with the aim to deliver molecules with the Right Safety profile. As well as: * Design and build in vitro and in vivo strategies to predict, assess, and mitigate on-target, off-target and drug-related safety risks and execute through internal and external experimental capabilities. * Develop innovative solutions and research proposals based on strategic needs of the discovery project portfolio, and to pursue cutting edge science and technologies in order to optimize and influence safety assessment of novel drugs. * Engage with world-class experts across our organization to develop, refine and implement innovative experimental strategies and use the data to assess and/or provide mechanistic understanding of safety issues. Essential Skills/Experience: * PhD (or equivalent) in toxicology, cell biology, pharmacology, systems biology or related field, and a strong scientific track record. Relevance on the job experience will also be considered. * Experience working with design of strategies and execution of in vitro and in vivo experiments to determine the safety of therapeutics (experience from different modalities e.g. small molecules, oligonucleotides, peptides and biologics). * Knowledge of advanced drug delivery and tissue targeting approaches across modalities. Understanding the safety aspects of targeted delivery. * Experience from doing Target Safety Assessments to identify on-target risks and setting up mitigation strategies. * Preferably >3 years' experience as Toxicologist in the drug discovery phase handling multiple drug projects in parallel. * Experience from external scientific collaborations. Experience of scientific mentorship e.g. leading work for a PhD student. The successful candidate is a highly motivated, creative and innovative scientist with a flexible, collaborative and team-oriented mindset. You like to solve problems in a goal-focused fashion and you have strong communication and presentation skills. Along with this, you have a social personality and will enjoy contributing to our open, positive, collaborative working climate. So, what's next? Are you ready to make a meaningful and lasting difference? Apply today and join us in our mission to push the boundaries of science and transform medicine! We look forward to your application, please submit both a resume and a personal letter. Please submit your application no later than August 10, 2025.

At AstraZeneca, we are an equal opportunity employer that puts patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, a team leader, thinking big and working together to make the impossible a reality. As part of the Global Human Resources team at AstraZeneca, you will have the opportunity to thrive in a fast-paced, creative and purposeful environment where bold, innovative thinking is encouraged. We believe our people are our greatest asset and are always looking for top talent whose curiosity, learning-agility and strong values orientation results in the delivery of high quality, impactful outcomes that accelerate our people and business success. We are seeking an HR Solutions Partner for a 12-month contract to support our Operations and IT divisions. In this role, you will work closely with HR Business Partners and HR Centres of Expertise (CoE) to deliver high-quality HR support to leaders and employees. Reporting to an HR Solutions Manager who oversees a global team of HR Solutions Partners, you will be based at our Gothenburg site-a vibrant hub of innovation, home to over 2,400 colleagues from more than 50 countries. Here, diversity is celebrated as a key driver of creativity, scientific progress, and meaningful change for patients across the globe. As an HR Solutions Partner, you will collaborate with HRBPs to provide expert guidance and coaching to managers and HR colleagues on all HR policies, processes, and programmes. You will play an important role in supporting business-specific HR initiatives in a fast-paced and evolving environment, helping to shape the future of AstraZeneca. If you are motivated by challenge, inspired by change, and committed to making a real-world impact, we encourage you to apply and join us on our journey to push the boundaries of science and talent development. Main Duties & Responsibilities: * Provide generalist HR advice on a range of employment related matters (e.g., disciplinary and grievance cases, attendance management, parental leave) and escalate to Employee Relations Specialist or COEs as appropriate * Work collaboratively with colleagues located in Global and Regional HR Center and HR Services teams in other countries to improve the customer experience, through accuracy and pace of delivery * Deliver sound generalist HR support, acting as a key point-of-contact and a trusted partner for provision of professional advice and support to a range of HR activities and programs * Ensure flawless execution of key people processes across the business - leading and supporting HRBP's with Performance Management, Reward, Employee Relations, change management, compensation and Workforce Planning processes * Co-design, lead and drive key HR project delivery within the BBU, in line with defined People Plan priorities, with support, coaching and guidance from the HRBPs * Deputise for HRBPs on key meetings and functional communication activity, where necessary * Maintain a high level of communication with all levels of the organization (both globally and locally) and positively impact the key decisions Essential Requirements: * Relevant HR experience * 0-2 years of HR experience * Bachelor's Degree * Practical experience providing HR advice to colleagues and senior leaders * Excellent analytical skills * Technical HR knowledge / skills associated one or more of the following disciplines - Resourcing, Performance & Reward, Employee Relations, L&D, organisational change * Attention to detail; accomplishes tasks and processes accurately and completely * Effective communicator and able to build relationships quickly * Self-starter, being able to deliver on own initiative and prioritise independently * Hunger for personal learning and self-driven development * Proven project management capability * Demonstrated ability to use Microsoft Office products is required (Word, Excel, Outlook, PowerPoint, Box) Desirable requirements: * Possesses knowledge and understanding of HR systems (Workday, ServiceNow) * Experience in managing / interacting with sizeable internal customer base * General knowledge and understanding of AZ policies and procedures Why AstraZeneca? At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us while we continue to build a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we are developing new ways to work, ground breaking methods, and bringing unexpected teams together. Interested? Come and join our team! So, what's next? Ready to make a difference? We will be reviewing applications ongoing, so apply now with your CV and cover letter, no later than 8th of July! Explore more about: Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Inclusion & Diversity at AstraZeneca: https://careers.astrazeneca.com/inclusion-diversity Sustainability at AstraZeneca: https://www.astrazeneca.com/sustainability/resources.html

Are you a passionate individual with expertise in mathematical modelling and pharmacokinetics-pharmacodynamics (PK/PD)? Do you want to contribute to the development of future treatments for cardiovascular, renal, and metabolic diseases? If so, we invite you to join our Modelling & Simulation team within the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca. This position is based at our dynamic R&D site in Gothenburg, Sweden. Accountabilities: As a Modelling and Simulation PK/PD expert, you will play a key role in shaping project strategies and driving critical decisions across our drug discovery portfolio. You will actively influence drug project teams, guiding the selection of targets, molecules, optimal dosing strategies, patient populations, and overall development pathways. You will have the opportunity to design and oversee the execution of complex studies in preclinical disease models, applying advanced mathematical modelling approaches to deliver impactful PK/PD and translational insights. Your expertise will enable you to synthesize data from multiple sources, predict human pharmacokinetics and pharmacodynamics, and influence the definition of efficacious exposure and dosing regimens. In this role, you will present and defend your quantitative assessments and recommendations to internal governance and senior stakeholders, shaping critical decisions at the highest levels. You will also provide scientific leadership by initiating and leading strategic DMPK and PK/PD innovation projects, fostering collaboration across disciplines, and representing AstraZeneca's modelling expertise both internally and within the broader scientific community. Essential Skills/Experience: * PhD in pharmacokinetics, pharmacology, mathematics, or related field, with a focus on model-based PK/PD approaches, preferably in a preclinical/translational setting * Industry or academic experience in exposure-response modelling (PK/PD, NLME, PBPK and/or QSP) including hands-on experience with scriptable modelling softwares (e.g., Phoenix, R, Matlab, Python, Monolix, NONMEM) * Demonstrated scientific leadership through a publication track record in relevant area * Excellent interpersonal skills and the ability to work in cross-functional teams * Excellent communication skills in English, both verbal and written Desirable Skills/Experience: * Experience in pharmaceutical research and development * Experience in PBPK modelling (e.g. Simcyp or PK-Sim) * Experience in defining quantitative modelling strategies across various therapeutic modalities (e.g., small molecules, oligonucleotides, peptides, proteins, antibodies or cell/gene therapy) At AstraZeneca, we are driven by results and use our unique blend of science and commercial knowledge to spot opportunities and drive outcomes. We are part of an expansive healthcare ecosystem that connects key players across the entire patient journey. Our patient-first approach informs every decision we make. We are committed to your development and believe that your best is better here. Join us and be part of a global team filled with the smartest minds. Ready to make your mark? Apply now and be a part of our journey to redefine the future of healthcare! Welcome with your application no later than July 2nd, 2025.