At AstraZeneca, we are dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your ambitious spirit. We currently have a new opportunity for an Enterprise Architect (EA), you'll be working with ground breaking technology. Care to join? The marriage between our purposeful work and the use of high-tech platforms is what sets us apart. We have an ambitious goal to lead the way in digital healthcare - from exploring data and AI, to working in the cloud on new technologies. You will join a team at the forefront. It's a dynamic and challenging environment to work in - but that's why we like it. Shape your own path, with support all the way. Diverse minds that work cross-functionally and inclusively together. Be part of a team that has the backing to innovate, disrupt an industry and change lives. Accountabilities: As an Enterprise Architect, you will be accountable for the IT capability and road map (1-5 years) for patient safety within R&D. Currently Patient safety is going through transformation form inhouse tools to cloud solutions that you will need to drive. This role is pivotal in contributing to the R&D patient safety domain and ensuring it is aligned with enterprise architecture across AstraZeneca. You will also be involved app rationalization, portfolio review, and architecture framework development. As an EA, you will ensure that common architecture decisions support both business and IS strategy within a domain focus. You will provide Enterprise Design thinking & support to AZ's Enterprise in one of the below focused domains of architecture: Business, Data, Application, Infrastructure. You will participate in Architecture Assessments & Reviews either as Reviewing Architect or as a Subject Matter Expert in the review team. You will also contribute to the development of the Architecture Capability within IS, by documenting and sharing knowledge and best practices with peer Architects and developing/maturing services aligned to architecture. Essential Skills/Experience: * Relevant technical degree or equivalent * Demonstrated technical depth & experience in at least one technical or architectural domain. * Experience influencing solution direction and standard adoption through the use of architecture capability building blocks, strategies, and roadmaps * Experience developing and leading innovative business capability definition and creation activities within one or more technical or architectural domain. * Proven experience influencing change and challenging approaches/ideas. * Experience developing and managing relationships with business stakeholders & third party suppliers * Experience working within and developing policies, procedures and guidelines within a secure, quality, and compliance environment * Strong collaboration skills with good internal/external links * Strong communication, facilitation and relationship building skills * Ability to interpret and communicate technical information into business language Desirable Skills/Experience: * Demonstrate initiative, strong customer orientation, and cross-cultural working * Understanding of the pharmaceutical/healthcare industry and of competitor activity, on a particular architecture and Information Management Technology at AstraZeneca is a home for purposeful disruptors! SO, WHAT'S NEXT? Are you already imagining yourself joining our team? Good, because we'd love to hear from you! Click the link to apply no later than May 6, and we'll be in touch as soon as we can. WHERE CAN I FIND OUT MORE? Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/ Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/ Why AstraZeneca? As Architects at AstraZeneca, we connect the dots across the business to improve the agility and functionality of our processes to accelerate AstraZeneca to the next level. We are champions of our Technology ecosystem, making sure the rest of the business experiences the true benefits of our systems. Uniting diverse areas and simplifying the way we work, changing mindsets and behaviours along the way. Our reach goes beyond technology. We are a collective of technical experts, bringing deep specialism and forward thinking to resolve complex ideas. We are curious about new ways of doing things to get to better solutions. For the business and our patients. Connecting the dots is what we do everyday, we are right at the heart of AstraZeneca's exciting digital transformation journey.

Are you an experienced scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now! Our team is growing and we are now looking to recruit a Senior Scientist experienced in histology with a background in image analysis and ideally experience with pathological assessment of immune-mediated diseases. If you have a drive for innovation and idea generation as well as excellent laboratory skills, this is a great opportunity to join the Bioscience In Vivo Department within Early Respiratory and Immunology. The role is located at our vibrant R&D site in Gothenburg, Sweden. Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases such as asthma, COPD, IPF, IBD, RA and SLE. The successful candidate will join a highly motivated team that works closely together with other departments focusing on Target Translational Science, Bioscience In vitro assays and Drug Metabolism/Pharmacokinetics to support discovery projects and to drive new exciting research. Are you ready to join us? What you'll do? As a Senior Scientist you will be a vital member of the department and in various working teams to progress our respiratory and immunological drug discovery projects. You will actively take part in scientific discussions, gain input from others and be involved in multiple project meetings to present and discuss experimental plans and data. This is a partly lab-based role where you will be actively involved in experimental phase of histological analyses, with responsibility to coordinate, perform and evaluate experiments as well as drive the establishment of new techniques. Characterization and validation of target expression and subsequent evaluation of engagement of the target by drug treatment in both patient and in vivo tissue samples will be key areas of your daily work. You will independently assess and report data with a clear understanding of its reliability, interpretation of findings and draw appropriate conclusions with input from others. We are looking for a great teammate with strong background in histology and related image analysis techniques with a specific focus on autoimmune and autoinflammatory diseases, ideally complemented by some experience in pathology and pre-clinical drug discovery processes. Essential for the role * PhD in a relevant field (area of Bioscience/Immunology) ideally complemented with experience of working in a drug discovery environment * Strong experimental histology skills in performing immunohistochemistry, istochemistry, in situ hybridization (including RNAscope) with automated machines (e.g. Ventana Discovery Ultra and Leica Bond) * Experience with immune cell identification and characterization (cluster of differentiation antigens, transcription factors, cytokines, etc)" * Knowledge in histology scoring and histomorphometry * Proven knowledge and experience in image analysis platforms (e.g. Visiopharm and Halo) * Understanding of statistical methods, quality control and data reporting/archiving * Be respectful, communicate openly and show effective collaborative behavior to obtain high quality study results * Excellent written and oral communication skills, including presentation skills. You are organized and incorporate the views of others in your communication and collaboration Desirable for the role * Knowledge of immune-mediated diseases, with a specific focus on gut, skin, joint, liver and/or kidney immunity including target and mechanism knowledge and basic understanding of pharmacokinetics * Some experience in pathology * Good understanding of pharmacology, physiology and immunology * Familiarity with deep learning image analysis methods, e.g. image segmentation and classification * Practical experience with a scripting language (Phyton, R) modelling tools * Knowledge in advanced histological techniques such as spatial transcriptomics, hyperplex staining and tissue optical clearing Why AstraZeneca? At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development. What's next? If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until May 10, 2024. Where can I find out more? Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Life in Gothenburg: https://www.movetogothenburg.com/ Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Are you an experienced in vivo Scientist ready to apply your skills in a diverse and dynamic company? If you can envision providing scientific expertise in a role that can impact patients' lives - join us now! We are looking for a Senior Scientist to join the In vivo Bioscience team within Research and Early Development, Respiratory & Immunology (R&I) in Gothenburg, Sweden. This is a great opportunity to be part of a highly dynamic team that works closely with other departments, focusing on Translational Science, Bioscience In vitro, Cell Therapy, and Drug Metabolism/Pharmacokinetics, to support drug discovery projects and drive new exciting research. Respiratory & Immunology is one of AstraZeneca's main therapy areas. From a research perspective, we work to understand, treat, modify and ultimately cure respiratory and autoimmune diseases. In this role, you will mainly focus on mouse models of inflammatory bowel disease (IBD). What you'll do? As a Senior Scientist you are a vital member of the in vivo community and you will contribute to identifying novel targets and progress drug discovery projects. You will actively take part in scientific discussions, represent the department in project meetings and gain input from other functions to incorporate in vitro, pharmacokinetic and translational data into the experimental design. This is a partially lab-based role where you will design, plan, execute and analyze pre-clinical in vivo studies with a specific focus on IBD models. You will independently assess and report data from in vivo studies with a clear understanding of its reliability, interpret findings and plan next steps. In this role you are an immunology expert, able to give advice and influence critical decisions to move projects forward. To strengthen team capabilities, you will lead internal and external collaborations (academic partners and CROs). Essential for the role * PhD in immunology, ideally complemented by postdoctoral and/or industry experience. * Profound knowledge in innate and adaptive immunity in the context of autoimmune and autoinflammatory diseases. * Hands-on ability to independently design and perform in vivo disease and mechanistic models with a particular focus on gut immunology and IBD * Experience with in vivo adoptive T cell transfer (naïve, Treg, CAR T) and subsequent ex vivo analysis. * At last 5 years of experience with regular FACS analysis of mouse samples (organ processing and digestion, cell staining, antibody panel set up, proficient in the use of BD FACS DIVA machines and Flowjo). * Experience with various cellular and molecular biology techniques for measuring proteins and gene expression to analyze ex vivo samples generated from in vivo studies. * Experience in maintaining the highest standards of animal welfare and ethical compliance. Familiar with using Good Statistical Practice in animal research and applying the 3R's. The successful candidate needs to show great time management and interpersonal skills in combination with excellent written and oral communication skills in English. Desirable for the role * Valid education required for compliance to work with live animals in Sweden. * Good understanding of pharmacology and PK/PD relationship in the context of in vivo studies. * Good written and oral communication skills in Swedish and experience in writing ethical applications for animal work in Sweden. * Experience in sorting cells at BD Cell Sorters. * Understanding practical aspects of the drug discovery process in the pharma industry. Why AstraZeneca in Gothenburg? Our Gothenburg site is one of AstraZeneca's three strategic R&D sites. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies. With more than 2,900 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life. What's next? If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until May 10, 2024. Where can I find out more? Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Life in Gothenburg: https://www.movetogothenburg.com/

Are you an experienced scientist with expertise in pharmacokinetics, pharmacology and drug metabolism (DMPK)? Would you like to apply your expertise in a global company that follows the science and turn ideas into life changing medicines? Then you could be the new colleague we are looking for! Our team is growing, and we are now looking for a motivated individual with experience in Biologics and/or small molecule drug development and PKPD, to join us as a DMPK Project Leader, from candidate selection to registration and beyond. This position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. Working at AstraZeneca means being entrepreneurial, following the science, scrutinizing data and details simultaneously with holistic thinking and through teamwork make progress. Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function, with research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into clinical development. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management. What you'll do? With a true passion for drug discovery you will support our portfolio within the R&I therapeutic area as a subject matter expert. In the DMPK project lead role you will work collaboratively with project representatives from other disciplines. These may include biology, safety , clinical pharmacology, pharmaceutical sciences, antibody Discovery/Protein Engineering and medicinal chemistry, where your task is to influence candidate profiling by providing the necessary DMPK support for clinical investigations. It is your responsibility to ensure delivery of all DMPK related activities throughout the value chain in accordance with regulatory requirements. These include preclinical PK experiments, in vitro ADME and biotransformation to yield pharmacokinetic understanding. Furthermore, assisting design of pharmacodynamic studies that ultimately delivers a pharmacological assessment underpinning human dose prediction and emerging clinical experience. You will work as the development DMPK representative on project teams from candidate selection to registration and beyond. We believe that you have a solid understanding of DMPK, a working knowledge of pharmacology, and that you will be able to provide expert advice and interpretation of complex nonclinical and clinical data. Main duties and responsibilities; * Communicate scientific progresses both externally and internally * Deliver DMPK input and data to projects within agreed timelines and to the right quality * Responsible for delivering and produce the nonclinical pharmacokinetic documentation to support clinical progression * Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy * Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made * Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies * Responsible for leading, coordinating and engaging with R&I DMPK colleagues in project related activities * Prepare clear presentations related to the above for internal governance bodies Your level of professional experience will be relevant for your initial career level (Associate Principal Scientist or Principal Scientist). ​Essential for the role * PhD or equivalent experience in a relevant field * Expert in DMPK sciences with profound knowledge of drug discovery and development processes * Broad experience in biologics drug development (PK & Bioanalysis) * Have PK modelling skills, experience of human PK and dose prediction, as well as an understanding of disease biology and PKPD * Experience with regulatory submissions for biologics and/or small molecules * Knowledge of all DMPK assays including the use of in silico tools for PK prediction * Experience in project leadership * Collaborative mindset * Team player * Proactive in providing expert support to project team and excellent communication skills Work policy When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. What's next! If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application until May 31, 2024. For more information about the position, please contact recruiting manager Lassina Badolo at [email protected] Where can I find out more? Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html Life in Gothenburg: https://www.movetogothenburg.com/ Culture and atmosphere of the Gothenburg site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/ Relocate to Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html